(R)-(-)-Ibuprofen-d3 is a deuterium labeled form of (R)-(-)-Ibuprofen, an R enantiomer of Ibuprofen. Inactive on COX, it inhibits NF-κB activation and exhibits anti-inflammatory and antinociceptive effects. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules as tracers for quantitation during drug development, with potential to affect pharmacokinetic and metabolic profiles.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS